A woman came with a severe visual impairments. During this 4 years numerous drug therapies had received to treat the tumor. However, tumur became cystic and very large. Dr. Guive Sharifi (neurosurgeon) with rhinology team for pituitary surgery led by Dr. Nader Akbari did endoscopic endonasal surgery and the tumor was drained completely. After surgery, the pituitary gland and Stalk maintain naturally that this is technically one of the most complicated surgeries in the world.